Custom Synthesis
ETA offers expertise in custom synthesis covering all aspects of organic and pharmaceutical chemistry. Our facilities are available for production of intermediates as well as Active Drug Substances under strictly conditions. Whether your need is a multi-step synthesis of 100 mg of a screening candidate or a scale-up to provide several kilograms of an advanced intermediate, you can be assured that your project will receive high priority and personal attention. All our Custom synthesis materials receive full characterization with high field NMR, mass spec, HPLC purity and a full certificate of analysis.

The services offered include:
Process development
Process optimization 
Scale up 
Full custom synthesis
Building blocks & scaffolds
Synthesis of small compound libraries

Contract Manufacturing
If you want to outsource the production of chemicals or ingredients, including Active Pharmaceutical Ingredients (APIs), advanced intermediates. We offer the facilities, knowledge, and experience you need. With a decade’s experience in custom synthesis and process development, we know how to move your product seamlessly from the laboratory into commercialization.
ETA have invested on several multi-purpose manufacturing facilities in different scale, which is available for production of your chemicals requirement from Single Kilogram for clinical trials to Multi-metric ton commercial quantities. You can always trust ETA to help you get your products to market faster by adding real value to your development process.
Confidentiality of proprietary information is strictly observed, If necessary a secrecy agreement is signed in advance.

R&D center
ETA's R&D center is located in Shanghai Zhangjiang Hi-Tech Park , China. Staffed with 2 Ph.D.from USA and 5 M.S. chemists in China, ETA is equipped with HPLC, GC, and other analytical instruments. Tests can be done on IR, GC/MS, LC/MS and 400NMR at the SIOC through contract. Our fully equipped research laboratories are dedicated to the route discovery, validation, and process development.
Once the projects come into our R&D center, our highly experienced chemists will conduct quick initial evaluation and offer you our proposal for further activities.
From first batch sample submission to pilot scale up and chemistry validation, we emphasize on the speed without compromising the quality. Our well-trained analytical chemists are responsible for method development supporting the process development team.Reactions can be carried out in up to 50L glass-lined vessels. High-pressure hydrogenation vessels and autoclaves are also available up to 10L.

Pilot Plan& Manufacturing
ETA has established and managed several state of the art facilities for the production of pharmaceutical intermediates and fine intermediates. The production units are fully equipped with state of art production blocks, secure warehousing capabilities for raw materials, dedicated powder processing units, quality control and assurance labs, engineering & building maintenance workshops, process development labs, solvent recovery plants and waste and toxic hazard management systems, sanitation systems, and comprehensive employee welfare facilities

Manufacturing Process include:
Hydrogination 
Grignard Reaction 
Fridel Crafts Reaction 
Aldol Condensation 
Ozonation 
Bromination 
Silylation
Estrification 
Chlorination 
Reduction 
Chiral Separation
Wittig Reaction
Vilsmeir – Haack Reaction 
Enzymatic Hydrolysis 
Stereo Selective Synthesis 
Condensation Reaction

Analysis
ETA operates state-of-the-art analytical labs equipped with the best in modern instrumentation.The labs is operated by experienced, qualified analytical professionals who offers open access, in process and problem solving support to ETA’s synthesis labs as well as providing comprehensive independent analysis data for all final compounds before shipment. 

Analytical Instrumentation
400 MHz, Bruker NMR, AVANCE III
LC/MS (Schimadzu, LC-20AD pump, LC-MS 2010EV detector)
HPLC (reverse phase, Schimadzu, UV/Vis SPD-20A, LC-20AT pump)
Gas Chromatography (GC-7890F )

QA

At ETA, we make quality the number one priority. We are constantly upgrading every aspect of our quality systems in terms of staff training, documentation and analytical capabilities to achieve the highest levels possible. Every product we ship includes a Certificate of Analysis with complete detailed information on lot number, product information, date of manufacturing, date of expiry, specification and typical analysis data. The quality of our products is one of our most significant assets.

Analytical Instrumentation include
400 MHz, Bruker NMR, AVANCE III
LC/MS (Schimadzu, LC-20AD pump, LC-MS 2010EV detector)
HPLC (reverse phase, Schimadzu, UV/Vis SPD-20A, LC-20AT pump)
Gas Chromatography (GC-7890F )